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More Than Just Pranks: An Interview With The John D. McCutcheon
by David Wallace
If there’s one thing I can say about John McCutcheon it’s that he’s got a good sense of humor. In fact, I think all of his humor is good, because when a guy can find the fun in making a scene with a doorknob, a
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See related research by Roche *et al.*,
In their article on ‘Clinical consequences of the rate and extent of tissue turn-over in breast cancer: how do they correlate with outcome?’ Roche *et al*. \[[@B1]\] used immunohistochemical techniques to examine levels of estrogen and progesterone receptors, Her2/neu, c-erbB-2 and Ki67 in sequential sections of 41 breast cancers. Cellularity in stromal tissue was assessed, and stromal-intracellular ratios were calculated. They found that none of the individual parameters correlated with disease-free interval (DFI). However, patients with a high stromal-intracellular ratio (S-I) had a significantly higher risk of tumor relapse and death.
The group chose to examine S-I in this study because it had been shown to be a powerful prognostic factor in the recently reported Nottingham study \[[@B2],[@B3]\]. By visual examination of each tumor section, several experts could make an independent assessment of the stromal and intracellular areas in the tissue. In their study, Roche *et al*. \[[@B1]\] examined tumor sections and determined S-I in a similar way. Given that outcome is primarily determined by local tumor extension, not