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The present invention relates to a disc cartridge of the type generally called a “jewel box” or “Jewel Box” which is used for storing a disc-like recording medium such as an optical disc (e.g. Compact Disc, etc.) or an optical magnetic disc (e.g. MO), and more specifically to a disc cartridge which is used for storing an optical disc such as a CD which is generally used for optical recording or reproducing of music and visual information or data of a computer or the like.
2. Related Background Art
An example of a disc cartridge of the above described type is described in, for example, Japanese Patent Publication No. 56-63094. This example uses a conventional optical disc adapted for magneto-optical recording and reproduction such as a “MO cartridge” which is adapted to be loaded in an optical disc drive unit to be rotated and to be magnetically recorded/reproduced.
This type of disc cartridge is characterized by having a rectangular cartridge case which contains a disc-like recording medium in a space defined therein and which is brought into a closed state by closing a lid for opening and closing a case main body.
Such a cartridge case is formed with a diameter-increased space in an outer periphery of the case main body for containing the disc-like recording medium which has a
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To develop a non-agglutinating glucose oxidase (GOD) preparation suitable for subcutaneous administration. nGOD was prepared by coprecipitation of GOD and beta-cyclodextrin. The nGOD was incorporated in Eudragit(R) (S-100)-based copolymer nanoparticles (NP) or into polymeric poly(lactic-co-glycolic acid) (PLGA) implants. The particles were characterized by scanning electron microscopy (SEM), light microscopy and photon correlation spectroscopy (PCS). Pseudoperiodic acid-Schiff staining was performed to assess the amount of nGOD associated with the cells. The rheological properties of the suspensions were studied using a cone-plate rheometer. The stability and in vitro enzymatic activity of nGOD were determined. The particles were spherical in shape with size ranged from 245 to 300 nm. nGOD was associated with the particles in a distribution of 15-60%. The particles were stable for at least one month, and exhibited excellent storage properties. nGOD was more stable and less immunogenic compared to the native GOD, and could be stored and formulated for subcutaneous administration in a simple, economical way. Moreover, no significant loss of enzymatic activity was observed for both, nGOD-based formulations. The nGOD-NP suspension was suitable for subcutaneous administration. The nGOD-PLGA implants did not degrade over one month. The rate of enzymatic reaction and the stability of the enzyme were comparable to the native GOD. The nGOD exhibited excellent physicochemical and biological properties, indicating that it may be used as a potential carrier for subcutaneous administration of GOD.The court heard how Mr Amos and Ms Sharp first met in prison.
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